TPP:Authors and Contributors

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The Trans-Proteomic Pipeline (TPP) is a collaborative open-source project. It was originally started at the Institute for Systems Biology (ISB) in the Aebersold Lab. The project has since grown, with active contributors from institutions all over the world. The ISB continues to provide primary support for the project, with other primary collaborators and contributors at Insilicos LLC, the University of Washington, Fred Hutch Cancer Research Center, and the University of Hong Kong.

Alphabetical by last name (current affiliation, if known): major work

Contents

primary authors (active)

  • Jimmy Eng (University of Washington, ISB): MS/MS spectra-to-peptide identification (SEQUEST)
  • Henry Lam (Hong Kong University of Science and Technology): spectral library search (SpectraST)
  • Luis Mendoza (ISB): graphic interface (Petunia)
  • Alexey Nesvizhskii (University of Michigan): statistical tools
  • Brian Pratt (Insilicos): optimization, data formats, windows installation
  • David Shteynberg (ISB): statistical tools within the TPP
  • Joe Slagel: cloud-based (AWS) workflow management
  • Natalie Tasman (Insilicos): cross-platform build and release and installation, data visualization, raw format conversion

other primary authors

  • James Eddes: MS spectra curation and quality assesment (QualScore)
  • Robert Hubley: original creator of cygwin-based Windows TPP distribution
  • Andrew Keller: statistical tools
  • Nichole King: iTRAQ-labeled quantification (Libra)
  • Xiao-jun Li: quantification (ASAPRatio)
  • Brendan MacLean: X!Tandem integration, testing, Visual Studio build
  • Patrick Pedrioli: mzXML open format creator, original work on file conversion
  • Ning Zhang: ProbID search engine (ProbID)

significant contributors and collaborators

  • Chee-Hong Wong (Fred Hutch Cancer Research Center): data format conversion (mzWiff)
  • Ted Holzman (Fred Hutch Cancer Research Center): MRM support in massWolf
  • Lukas Reiter (Swiss Federal Institute of Technology Zurich): protein identification false discovery rates (Mayu)
  • ProteoWizard project: file format conversion. Included in TPP; TPP authors contribute back to main project.
  • Labkey Software(formerly CPAS): Testing of TPP
  • X!Tandem: open-source MS/MS search engine. Included in TPP. TPP authors update and offer improvements to original code.
  • Aebersold Lab Seattle (ISB) and Zurich: support, testing, feedback

other contributors

  • Rune P: special processing in massWolf
  • Sergey Doronin: CProbID: c-language implementation of ProbID search engine


  • and all of the many people from the newsgroup who have contributed patches, bug reports,
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